Mr Rajan

MD MS FRCS Edin. FRCS Glas. FRCOphth
Professor Rajan is an ophthalmic surgeon and clinical academic based in Cambridge with expertise in cataract surgery, advanced optic intraocular lenses and corneal disorders.
Cambridge Vision Clinic Team led by Professor Rajan provides personalised care for patients and it is consultant delivered throughout initial consultation, surgery and follow up visits.

Present appointments



  • FRCOphth, London
  • MD, University of London
  • MRCOphth, London
  • FRCS Glasg. (Ophthalmology)
  • FRCS Ed (Ophthalmology)
  • MS (Ophthalmology)
  • MBBS

Clinical Experience

Madhavan Rajan qualified in 1994 and underwent specialist ophthalmic training in London and has 18 years experience in ophthalmology. His interest in cataract, cornea and refractive surgery led to a research fellowship in laser refractive surgery at St Thomas’ Hospital, London culminating in a MD degree at the University of London. Subsequently, he spent 2 years as corneal, refractive and external eye diseases fellow at Moorfield’s Eye Hospital, London.
He was appointed consultant ophthalmic surgeon in 2007 and he is clinical lead of cornea and cataract service at Addenbrooke’s Hospital Cambridge and principal supervisor for the corneal fellowship programme. He was appointed as Professor of ophthalmic and Visual Sciences to Anglia Ruskin University, Cambridge in 2010. At the Vision and Eye Research Unit (VERU), he leads a corneal research team with basic science researchers and PhD studentships focused on corneal transplant research, corneal therapeutics, corneal stem cells and advanced intraocular lenses and has several publications in peer reviewed literature. Professor Rajan and his team had recently developed a novel endothelial keratoplasty technique termed Microthin DSAEK with improved patient outcomes, that won the NHS Health enterprise Innovation award.
Mr Rajan is a keen golfer and enjoys his rambling weekends in the Lakes, Dales and the Peaks. He values his time with the family and he is blessed with 4 children (two teenage daughters and twin boys)

Clinical interests and expertise

Cataract and Refractive Surgery
  • Microincisional cataract surgery
  • Refractive lens exchange
  • Refractive surgery and Presbyopia surgery
  • Premium Intraocular lenses – Toric and Multifocal IOLs
Cornea and External eye diseases
  • Corneal transplantation – Endothelial keratoplasty / Anterior lamellar keratoplasty
  • Kerataconus and corneal cross linking treatment
  • Dry eyes and ocular surface reconstruction surgery
  • Corneal infections
  • Immune mediated ocular surface disorders
Supervisory Role
Principle supervisor for two corneal and cataract fellows at Addenbrooke’s and undertake educational supervisory role for specialist ophthalmic trainees in the East of England and a PhD studentship at Anglia Ruskin University.
Professional Membership: General Medical Council, The Royal College of Ophthalmologists, London, UK and Ireland Cataract and Refractive Surgeons Society, European Cociety of Cataract and Refractive Surgeons, American Society of Cataract and Refractive Surgeons, UK Bowman corneal clubmember, British Refractive Surgeons society.

Research interests & expertise

  • Isolation and ex vivo culture of corneal endothelial cell precursors
  • Development of corneal drug delivery device
  • Temporal characteristics of endothelial graft thickness and visual recovery in manual and automated corneal endothelial keratoplasty
  • Developing strategies to optimize visual outcome in corneal transplantation
  • Advanced IOL technology


  • Visiting consultant to Lifeline express cataract charity in China
  • Children’s charity in UK & Abroad
  • Trustee to Cambridge Eye Trust Charity, Cambridge

Recent peer reviewed scientific publications

  • 1: Rolev K, Coussons P, King L, Rajan M. Experimental models of corneal endothelial cell therapy and translational challenges to clinical practice. Exp Eye Res. 2019 Nov;188:107794. doi: 10.1016/j.exer.2019.107794. Epub 2019 Sep 10. PMID: 31518569.
  • 2: Rolev K, OʼDonovan DG, Coussons P, King L, Rajan MS. Feasibility Study of Human Corneal Endothelial Cell Transplantation Using an In Vitro Human Corneal Model. Cornea. 2018 Jun;37(6):778-784. doi: 10.1097/ICO.0000000000001555. PMID: 29521691.
  • 3: Bowes OMB, Shah P, Rana M, Farrell S, Rajan MS. Quality indicators in a community optometrist led cataract shared care scheme. Ophthalmic Physiol Opt. 2018 Mar;38(2):183-192. doi: 10.1111/opo.12444. Epub 2018 Feb 5. PMID: 29405327.
  • 4: Weber IP, Rana M, Thomas PBM, Dimov IB, Franze K, Rajan MS. Effect of vital dyes on human corneal endothelium and elasticity of Descemet’s membrane. PLoS One. 2017 Sep 13;12(9):e0184375. doi: 10.1371/journal.pone.0184375. PMID: 28902856; PMCID: PMC5597301.
  • 5: Rolev K, O’Donovan DG, Georgiou C, Rajan MS, Chittka A. Identification of Prdm genes in human corneal endothelium. Exp Eye Res. 2017 Jun;159:114-122. doi: 10.1016/j.exer.2017.02.009. Epub 2017 Feb 20. PMID: 28228349; PMCID: PMC5451076.
  • 6: Roberts HW, Mukherjee A, Aichner H, Rajan MS. Visual Outcomes and Graft Thickness in Microthin DSAEK—One-Year Results. Cornea. 2015 Nov;34(11):1345-50. doi: 10.1097/ICO.0000000000000596. PMID: 26312621.
  • 7: Voyatzis G, Roberts HW, Keenan J, Rajan MS. Cambridgeshire cataract shared care model: community optometrist-delivered postoperative discharge scheme. Br J Ophthalmol. 2014 Jun;98(6):760-4. doi: 10.1136/bjophthalmol-2013-304636. Epub 2014 Feb 10. PMID: 24515987.
  • 8: Rajan MS. Surgical strategies to improve visual outcomes in corneal transplantation. Eye (Lond). 2014 Feb;28(2):196-201. doi: 10.1038/eye.2013.279. Epub 2014 Jan 3. PMID: 24384964; PMCID: PMC3930281.
  • 9: Thomas PB, Mukherjee AN, O'Donovan D, Rajan MS. Preconditioned donor corneal thickness for microthin endothelial keratoplasty. Cornea. 2013 Jul;32(7):e173-8. doi: 10.1097/ICO.0b013e3182912fd2. PMID: 23665648.
  • 10: Hyatt AJ, Rajan MS, Burling K, Ellington MJ, Tassoni A, Martin KR. Release of vancomycin and gentamicin from a contact lens versus a fibrin coating applied to a contact lens. Invest Ophthalmol Vis Sci. 2012 Apr 18;53(4):1946-52. doi: 10.1167/iovs.11-8607. PMID: 22408014.
  • 11: Hayes S, Boote C, Kamma-Lorger CS, Rajan MS, Harris J, Dooley E, Hawksworth N, Hiller J, Terill NJ, Hafezi F, Brahma AK, Quantock AJ, Meek KM. Riboflavin/UVA collagen cross-linking-induced changes in normal and keratoconus corneal stroma. PLoS One. 2011;6(8):e22405. doi: 10.1371/journal.pone.0022405. Epub 2011 Aug 5. PMID: 21850225; PMCID: PMC3151245.
  • 12: Daniel CS, Rajan MS, Saw VP, Claerhout I, Kestelyn P, Dart JK. Contact lens- related Fusarium keratitis in London and Ghent. Eye (Lond). 2009 Feb;23(2):484-5. doi: 10.1038/eye.2008.188. Epub 2008 Jul 4. PMID: 18600249.
  • 13: Shortt AJ, Secker GA, Rajan MS, Meligonis G, Dart JK, Tuft SJ, Daniels JT. Ex vivo expansion and transplantation of limbal epithelial stem cells. Ophthalmology. 2008 Nov;115(11):1989-97. doi: 10.1016/j.ophtha.2008.04.039. Epub 2008 Jun 13. PMID: 18554721.
  • 14: Rajan MS, Bunce C, Tuft S. Interocular axial length difference and age- related cataract. J Cataract Refract Surg. 2008 Jan;34(1):76-9. doi: 10.1016/j.jcrs.2007.08.023. PMID: 18165085.
  • 15: Rajan MS, O'Brart D, Jaycock P, Marshall J. Effects of ablation diameter on long-term refractive stability and corneal transparency after photorefractive keratectomy. Ophthalmology. 2006 Oct;113(10):1798-806. doi: 10.1016/j.ophtha.2006.06.030. PMID: 17011958.
  • 16: Rajan MS, O'Brart DP, Patmore A, Marshall J. Cellular effects of mitomycin-C on human corneas after photorefractive keratectomy. J Cataract Refract Surg. 2006 Oct;32(10):1741-7. doi: 10.1016/j.jcrs.2006.05.014. PMID: 17010877.
  • 17: Rajan MS, O'Brart DP, Patel P, Falcon MG, Marshall J. Topography-guided customized laser-assisted subepithelial keratectomy for the treatment of postkeratoplasty astigmatism. J Cataract Refract Surg. 2006 Jun;32(6):949-57. doi: 10.1016/j.jcrs.2006.02.036. PMID: 16814052.
  • 18: Rajan MS, Pantelidis P, Tong CY, French GL, Graham EM, Stanford MR. Diagnosis of Treponema pallidum in vitreous samples using real time polymerase chain reaction. Br J Ophthalmol. 2006 May;90(5):647-8. doi: 10.1136/bjo.2005.083196. PMID: 16622098; PMCID: PMC1857041.
  • 19: Rajan MS, Watters W, Patmore A, Marshall J. In vitro human corneal model to investigate stromal epithelial interactions following refractive surgery. J Cataract Refract Surg. 2005 Sep;31(9):1789-801. doi: 10.1016/j.jcrs.2005.02.047. PMID: 16246786.
  • 20: Jaycock PD, O'Brart DP, Rajan MS, Marshall J. 5-year follow-up of LASIK for hyperopia. Ophthalmology. 2005 Feb;112(2):191-9. doi: 10.1016/j.ophtha.2004.09.017. PMID: 15691550.
  • 21: Rajan MS, Shafiei S, Mohrenfels CV, Patmore A, Lohmann C, Marshall J, Hamberg-Nystrom H. Effect of exogenous keratinocyte growth factor on corneal epithelial migration after photorefractive keratectomy. J Cataract Refract Surg. 2004 Oct;30(10):2200-6. doi: 10.1016/j.jcrs.2004.02.022. PMID: 15474836.
  • 22: Rajan MS, Jaycock P, O'Brart D, Nystrom HH, Marshall J. A long-term study of photorefractive keratectomy; 12-year follow-up. Ophthalmology. 2004 Oct;111(10):1813-24. doi: 10.1016/j.ophtha.2004.05.019. PMID: 15465541.
  • 23: Sobha S, Rajan MS, Jackson H. Choroidal neovascularization following hyperopic LASIK surgery. Clin Exp Ophthalmol. 2004 Aug;32(4):443-5. doi: 10.1111/j.1442-9071.2004.00854.x. PMID: 15281987.
  • 24: Kielhorn I, Rajan MS, Tesha PM, Subryan VR, Bell JA. Clinical assessment of the Zeiss IOLMaster. J Cataract Refract Surg. 2003 Mar;29(3):518-22. doi: 10.1016/s0886-3350(02)01819-9. PMID: 12663017.
  • 25: Rajan MS, Syam P, Liu C. Systemic side effects of topical latanoprost. Eye (Lond). 2003 Apr;17(3):442-4. doi: 10.1038/sj.eye.6700351. PMID: 12724721.
  • 26: Rajan MS, Bremner FD, Riordan-Eva P. Pupil perimetry in the diagnosis of functional visual field loss. J R Soc Med. 2002 Oct;95(10):498-500. doi: 10.1258/jrsm.95.10.498. PMID: 12356970; PMCID: PMC1279175.
  • 27: Rajan MS, Keilhorn I, Bell JA. Partial coherence laser interferometry vs conventional ultrasound biometry in intraocular lens power calculations. Eye (Lond). 2002 Sep;16(5):552-6. doi: 10.1038/sj.eye.6700157. PMID: 12194067.
Load More
01223 266 913
About Us

Cambridge Vision Clinic based in Cambridge, UK features an excellent team of eye care professionals offering a personalised, safe approach to patients with cataract and eye disorders for over 10 years.


Email: info@cambridgevisionclinic.org
Phone: 01223 266 913
Fax: 01223 266 958